European Prevention Center


To increase Happiness and Longevity


To reduce Morbidity and Mortality


From Prediction to Prevention

Actual Aspects of Corona Pandemia

Quelle: Frankfurter Rundschau
Official EPC statement „Practical behaviour and circumstances informations / recommendations to SARSCoV-2 (severe acute respiratory syndrome Coronavirus-2) und COVID-19 (Coronarvirus Disease 2019) within occupational health management (OHM) by Uwe Nixdorff, M.D., Associate Professor; Internist, Cardiologist for EPC GmbH - European Prevention Center ( and Hanako GmbH (

A webinar of BVMW (Bundesverband Mittelständischer Wirtschaft) held at 6th May 2020 presented medical and oeconomic aspects of Corona pandemia.

Prof. Nixdorff is cooptive executive member of the healh commission of BVMW.

Ab dem 01. Oktober 2020 ist nunmehr auch der SARS-CoV-2 Rapid Antigen-Test von Roche im EPC vorhanden.
Mit einer Sensitivität von 96,5% und Spezifität von 99,7% kann jetzt nachgewiesen werden, ob eine akute Corona-Infektion vorliegt. Dies ist insbesondere bei klinischen Verdachtsfällen sinnvoll!

Prof. Dr. med. Uwe Nixdorff

Prof. Nixdorff is the founder of the European Prevention Center (EPC), which was founded in March 2005 in Munich. Check-up examinations in comprehensive algorithms including Whole-body magnetic resonance imaging (WB-MRI) are being implemented in the business sector (b-to-b). This was preceded by extensive scientific work on the principles of risk stratification, early detection, and consecutive prevention measures at Friedrich Alexander University Erlangen-Nuremberg, Leibniz Institute for Arteriosclerosis Research at University Hospital Munster and at the Cooper Institute, Dallas / Texas, USA. Location is Dusseldorf; other historical locations are Berlin, Duisburg, Munich; whereby a "rollout" with the high quality claim and assurance as well as the special attention with the motivational goal of lifestyle modification could not prove true. In standardized and scaled form, the mobile service offering through programmed / digital implementation of the EPC experience is taken into account by the further establishment of Hanako ( in the area of wider workplace health management.
Prof. Dr. Uwe Nixdorff
Curriculum Vitae
Curriculum Vitae
Publication List

The HEARTy EPC team

M. Guderjahn

Senior MFA

Prof. Dr. med. U. Nixdorff

CEO of the EPC
Curriculum Vitae

G. Ernst

Senior Consultant

L. Aßmann

Key Account Managerin

F. Preuss
F. Preuss


Impressions of
EPC Roomings

The provision of own lounges with own sanitary incl. shower units for EPC customers allow - within the whole day check-up program – a wellbeing atmosphere, in which also the visit (anamnesis and consultation) of the preventive medical doctor is positioned.



Simple check-up version with basic laboratory and non-radiological sectional image diagnostics


Basic check-up variant with higher spatial resolution through abdominal MRI


Extensive, mostly selected check-up option including full-body MRI

Cross-sectional imaging:Ultrasound abdominal organsMRI abdomenMRI whole body
Duration:5 hours6 hours7 hours
Current detailed anamnesis and prehistory
As part of the medical history:
For nicotine dependence: Questionnaire on physical nicotine dependence as a basis for smoking cessation (Fagerström test)
Standardized questionnaire on well-being after WHO as a basis for lifestyle advice--
Risk factor analysis (PROCAM Score)
Anthropometry incl. bioimpedance analysis
Measurements and calculations of body mass index (BMI), waist and hip circumference [whaist-to-hip ratio (WHR), whaist-to-height ratio (WHtR)] and body composition (fat, water, biomass).
Oxygen saturation (pulse oximetry)
In-depth physical examination
Screening laboratoryBasic laboratoryBasic laboratoryEXTENDED
Differential blood analysis (large blood analysis) incl. differentiation of white blood analysis
Blood sugar levels:
-Fasting blood sugar, HbA1c
-Basal insulin (including HOMA index)

Cholesterol status:
-Total cholesterol, HDL, LDL cholesterol and triglycerides
-Apolipoprotein B
-Apolipoprotein A1



Liver/biliary/pancreatic values: Gamma-GT, GOT, GPT, LDH, cholinesterase, bilirubin, lipase, amylase, alkaline phosphatase
Renal values: creatinine, urea, uric acid
Musculature: creatine kinase
Calcium, chloride, potassium, sodium, magnesium, ferritin
Coagulation values:
-INR (Quick), PTT, fibrinogen
-APC resistance



Protein analysis: total protein and protein electrophoresis
Thyroid hormone status:
-TSH basal (LIA)
-fT3, fT4



Urine status: pH, leucocytes, protein, glucose, ketone, erythrocytes, urobilinogen, nitrite, density, bilirubin;
including Micraltest (microalbumin)
Stool examination:
-Hemoccult test
-ScheBo® o 2in1 Quick ™ - stool test (immunological stool test)


Bladder cancer screening:
-NMP22® BladderChek® urine bladder cancer screening (immunological urine test)
Emerging risk factors:
- high sensitive CRP
- lipoprotein (a)
- homocysteine



Arterial plaque activity:
Lipoprotein-associated phospholipase A2 (Lp-PLA2)
Cardiac marker: NT-proBNP--
Omega-3 Index--
Vitamin D (25-hydroxy vitamin D)--
Immunoglobulins: IgA, IgG, IgM, IgE--
Men's laboratory (in men over 40 years of age)
-free PSA [if applicable]
-Sex hormone-binding globulin (SHBG) with calculation of androgen index



Instrumental examination of the organs and vessels
Ultrasound of the abdominal organs--
Whole-body MRI and whole-body MR angiography: visualization of the entire organ, muscle and vascular system and representation of the entire spinal column (longitudinal and transverse section) and differentiation of degenerative changes (eg herniated disc)-
(MRI abdomen)

(MRI whole body)
Duplex sonography of neck arteries incl. age and gender referenced intima media thickness measurement
Sonography of the thyroid gland
Fitness assessment (cardiovascular check)
Ergospirometry with ECG incl. lung function
Heart rate variability (HRV) for recording stress level
Doppler echocardiography
Tissue Doppler echocardiography
Real-time 3D echocardiography (for cardiac)
Pulse wave analysis (PWA)
including determination of the ABI index (ankle-brachial index)
Further investigations
Auditory test (audiometry)
Eye fundus examination (TalkingEye) (ophthalmological specialist)
Skin screening (dermatological specialist)--
According indication
- oral glucose tolerance test (oGTT)
- Long-term ECG (for arrhythmias)
- Long-term blood pressure (for high blood pressure)
- Somnocheck (sleep screening)
Final discussion / findings folder
Detailed final discussion, illustration and interpretation of all imaging findings
Lifestyle advice, based on individual findings
Written general comprehensible final report with CD-ROM of MRI (CT) images



Additional specialist medical services can be scheduled on the same check-up day or in a timely manner. The results of the study are interdisciplinary integrated into the full-body check-up by the supervising EPC preventive physician.
The definition of additional services is resulting of individual wishes, but partly also by individual risk constellations. Those are executed by actual guidelines of the medical societies. A consultative discussion eighter at the centre or by phone provided by an expert preventive physician for planing the check-up is essential.


  • Cardiovascular - I
    Coronary calcium scoring (CACS): multi-detector computed tomography (MDCT) of the heart without contrast agent [selectable with justifiable indication]

  • Cardiovascular - II
    Noninvasive Coronary Angiography (CCTA): Multilayer Computed Tomography (MSCT) of the Heart Contrast media - [selectable with justifiable indication]

  • Cardiovascular - III
    Stress echocardiography - Imaging ischemia diagnosis (question of circulatory disturbances of the heart muscle) - [selectable with justifiable indication]

  • Male care (urology / andrology)

  • Women's care (gynaecology)

  • Intestinal Check-Up "Virtual"

  • Bowel Check-Up "Conventional" incl. Histology

  • Gastroduodenoscopy (gastric / duodenoscopy) incl. Histology

  • Lung check-up (for smokers) [with justifiable indication]

  • Smoking cessation

  • Musculoskeletal system / orthopedics

  • Rheumatism check-up

  • Ears, nose & throat (ENT) check-up

  • Allergy check-up

  • Vein check-up

  • Dental check-up

  • Burnout prophylaxis and stress management

  • Dedicated MRI at indication, e.g. knee, hip, spine section



"For our company, we were looking for a partner who, on the one hand could garanty the provision of health care for our executives, who supported the preservation of the health of our high-performers and at the same time showed loyalty and care from the company, which could further strengthen our leadership circle. Companies want loyalty from employees and executives. Bonding and loyal behavior are always two-sided. With the provision of health care, a company shows care, responsibility and loyalty in the most important area of human life. Therefore, a few years ago we decided to realize this fundamentally sensitive topic with a particularly competent and trustworthy partner. After a selection process we decided on Prof. Uwe Nixdorff.

The feedback from our colleagues in the management circle was overwhelming. Not only that the medical examinations by specialists of the relevant orientations were very convincing. The cardiological area was covered by Prof. Nixdorff personally. In particular, the inclusion of patients at eye level in findings of preventive testing inspired all participants of the program. The final discussion with Prof. Nixdorff was always considered a highlight. It was described that in completely transparent and comprehensible form all results were discussed in a calm and time pressure free atmosphere and the derivations of it could be discussed. This was not limited to medical facts, but a true life coaching was also part of the conversation. Also nutrition and sports program could be planned. The entire program with the concluding consultation had a highly motivating effect on the further behavior and caused honest gratitude compared to the previous session. The feedback from our executives did not surprise me, but confirmed my own experience, as I was the first to participate in the program on a trial basis.

The preventive program according to the method of Prof. Uwe Nixdorf has become a solid and particularly valuable part of our management support and has a strong influence on trust and culture in our management circle. "



"For me, Prof. Dr. med. Uwe Nixdorff counts to the best experts of preventive medicine in the country. His executive program also has a very special significance for our company. Both the comprehensive medical examinations of the specialists and the intensive personal care of the patients are in my opinion unique. Particularly noteworthy is the final discussion, in which Prof. Dr. Nixdorff discusses in detail all the results with the patients - in a language understandable even to medical laymen. Added to this is the excellent patient-tailored advice that covers many areas of life (including nutrition and lifestyle). All in all, Prof. Dr. Nixdorff initiated a preventive program which for me is an essential milestone in comprehensive preventive care, which is unparalleled and which I can highly recommend to any company. "


The health of our employees is important to us and prevention is important. That's why we offer our executives regular health checks. We know this with Prof. Dr. med. Nixdorff in the best hands. As a trusting partner, he stands by each and every one of them with help and advice.


"Prof. Dr. med. Uwe Nixdorff counts to the best experts of preventive medicine in the country. The program for executives also has a very special status for our entrepreneurs in the SME sector. With the provision of preventive health care, a company in its most important area of ​​life shows care, responsibility and loyalty to its employees. Already during the comprehensive medical examinations by specialists, Prof. Nixdorff offers a unique personal care for the patients. Particularly noteworthy is the final discussion, in which he discusses all the results with the patients in detail in a language that is understandable even to medical laymen. All in all, the preventive program initiated by Prof. Nixdorff is an important milestone in holistic prevention, which has no equal and which I therefore like to suggest to every company. "


Worth knowing from the EPC

In a holistic textbook on the subject of evidence-based disease prevention, all important medical disciplines with their significance of preventive medicine are presented and finally complemented with complementary methods as well as the salutogenetic concept. The book is currently sold out and is currently still available as an e-book. Check-Up-Medizin bei Amazon kaufen

In this textbook of the European Society of Cardiology, Prof. Nixdorff and co-authors Prof. Achenbach, Prof. Nagel, Prof. Zamorano, and others show responsible for the topic "Imaging in Cardiovascular Prevention". The book provides a complete overview of the evidence of preventive cardiology.

Check-Up-Medizin bei Amazon kaufen

"30 minutes future"


Future Thinker Interview with Prof. Dr. Uwe Nixdorff


2021 European Guidelines on cardiovascular disease prevention in clinical practice


Auf dem Boden der wissenschaftlichen Präventionsleitlinie der European Society of Cardiology (ESC) 2021 werden im EPC die Check-Up-Proceduren durchgeführt.

Acute coronary syndrome


In honor of the 80th birthday of the scientific teacher of Prof. Nixdorff, Prof. Meyer (Emeritus of the Medical Clinic II of the Johannes Gutenberg University Hospital Mainz), a current HERZ issue, Springer Verlag, with the topic "Acute Coronary Syndrome", for which Prof. Nixdorff wrote the preventive aspect, was published.


U. Nixdorff,  G. Horstick,  A. Schlitt, Herz – Cardiovascular Diseases, 2019; 44:45-52

DOI 10.1007/s00059-019-4782-y

Dissertations at the EPC

The EPC's check-up data are evaluated scientifically (anonymously) in current doctoral theses in cooperation with various university institutions, currently mostly in cross-sectional studies, but soon also in longitudinal studies, since there is still considerable need for research on check-up outcome research.

Completed work from EPC series:

  1. „Check-up-Medizin in der Sekundärprävention: Rationale der Ganzkörper-Magnetresonanztomographie des asymptomatischen Individuums“

Ongoing work on EPC series:

  1. “Number Needed to Screen in der Früherkennung der Atherosklerose: Ist der kardiovaskuläre Check-up rational und rationell?“
  2. „Der Omega-3-Index als cardiovasculärer Risikomarker. Gibt es Korrelationen mit traditionellen und neueren kardiovaskulären Risikomarkern?“
  3. „ Rationale der evidenzbasierten Check-Up-Medizin: Zur Umsetzung der Früherkennungs- in Vorsorgemedizin “
  4. „White matter hyperintensities als Präventivfaktor in Bezug zum kardiovaskulärem Risikoprofil“
  5. „Klinische Validierung eines mikrodiagnostischen Meßsystems für das Schlafapnoescreening und mit gleichzeitiger plethysmographischer Pulswellenanalyse zur erweiterten kardiovaskulären Risikostratifizierung“
  6. „Geschlechts- und altersabgeleitetes Normogramm zur tonometrisch erfassten Pulswellenanalyse aus einem kardiovaskulär risikobeurteilten Normalkollektiv“
  7. „Der arteriovenöse Quotient des Augenhintergrunds in der kardiovaskulären Risikostratifikation. Beziehung zu PROCAM-Score, Pulswellenanalyse und karotidaler Intima-Media-Dicke“

Zukünftiges aus dem EPC

Für Präventivmediziner

Symposium "Current pulse wave and endothelial measurements in the spectrum of evidence-based cardiovascular check-up medicine"

Scientific Directors: Prof. Dr. med. U. Nixdorff; Dr. med. J. Baulmann
Zeit: aufgrund der Corona-Pandemie auf unbestimmt verlegt

Location: European Prevention Center at the Medical Center Düsseldorf, Luise-Rainer-Str. 6-10, 40235 Dusseldorf

(Symposium with appreciation of the new ESC / ESH Guidelines 2018 on arterial hypertension incl. Hands-on at the most important device manufacturers, CME points of the Ärztekammer Nordrhein and patronage of the DGK, BNK and DeGAG)


Vergangenes aus dem EPC

International Conferences on
Personalized MedicinE

Here you can find the schedule of both days as a PDF.

Here, the program of symposium can be recognized as PDF file.

„Wertschöpfung durch Wertschätzung“
– Netzwerken –
BREAK SLOW am 13.02.2020

Im Medical Center Düsseldorf (GrandArc),
Luise Rainer Str. 6-10, 40235 Düsseldorf
Parkmöglichkeiten in der Tiefgarage des Zentrums

Wertschöpfung durch Wertschätzung
18.00 Uhr Begrüßung Moderation Sabine Grosser
18.10 Uhr Impulsvortrag Prof. Dr. med. U. Nixdorff, FESC
21.00 Uhr Ende der Veranstaltung

Die Teilnehmerzahl für diese exklusive Veranstaltung ist limitiert. Bitte melden Sie sich rechtzeitig an.

Prof. Dr. med. U. Nixdorff, FESC
Geschäftsführender Gesellschafter; Internist, Kardiologe, Sportmediziner, EPC GmbH – European Prevention Center (EPC)

Wir sind in der Weltwirtschaft nun im Übergang von der lang anhaltenden Welle der Informationstechnologie zu Human Resources (6. Kondratieff-Zyklus). Nur das Unternehmen, das sich auf grundlegende Wertschöpfung und damit beinhaltet das Gesundheitsmanagement (BGM) im HR Bereich proaktiv fokussiert, kann die immer komplexer werdenden Herausforderungen meistern. Personal kann nicht mehr mit antiquierter Verwertung der Schaffenskraft geführt werden (bis nichts mehr geht, bis zum burn-out), sondern es ist als DIE Wertschöpfungsgrundlage wert zu schätzen. Wie das geht, erläutert Prof. Dr. Nixdorff in seinem spannenden Vortrag und zeigt uns die Räumlichkeiten seiner hochmodernen Präventions-Praxis.

Serielle Kunstausstellungen im EPC

Periodical art exhibitions in the EPC

Since automn 2018 serial art exhibitions are settled in a half year cycle at the EPC, which are framed by opening as well as finalising events. The first exhibition has been performed 10/2018 – 01/2019 by renowned digital artist Ralph Hegewald, Düsseldorf.

Natur in Komposition

A second exhibition is a colourful foto series of carneval from Rio with the name „Allegria“ by fotographer Prof. Dr. med. E. Vester, who until recently had been cardiology director of Evangelisches Krankenhaus Düsseldorf, specialized in rhythmology with comprehensive scientific activity and international reputation.

Aufgrund der Coronarvirus-Pandemie wird die geplante Kunstausstellung auf unbestimmte Zeit verlegt.

The following, i.e. third exhibition will be given by the also reputated artist Rosario Buccellato ( The date of vernissage will be annonced next time.

Glaesern - Kopfstoss - Brueghelsengel
Gläsern - Kopfstoß - Brueghelsengel
2011 | Öl, Canvas | 175 x 200 cm

Activities in
Scientific Societies

European Society of Cardiology

European Society of Cardiology (ESC)

Prof. Nixdorff had actively participated in various accreditations in the field of imaging; also on the curriculum of the "European Cardiologist"; currently member of the Deployment Endorsement Policy / Task Force Live Events. The company represents the approximately 60,000 cardiologists in Europe. There is an extensive arsenal of scientific guidelines that make up the evidence base in the EPC.

European Association of Preventive Cardiology

European Association of Preventive Cardiology (EAPC)

Prof. Nixdorff is a member of the Executive Board; Speaker of the Communication Committee; furthermore Consultant of the Section Prevention, Epidemiology & Population Science (PEP). Within the ESC, the concern of the prevention cardiology is addressed, as is underlined by a current projective accreditation for prevention centers by the EPC as a pilot center.

Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung (DGK)

Prof. Nixdorff was Chairman of the Cardiovascular Ultrasound Working Group as well as cluster spokespersons of the Imaging Working Groups (Echo, MRI, CT, Nuclear); in consequence also chairman of the working group for preventive cardiology. Training activity in the Academy of the DGK. The company represents approx. 8,000 cardiologists in Germany.

The EPC has been accredited as one of the first European prevention centres by the EAPC (European Association of Preventive Cardiology) of the ESC (European Society of Cardiology). An overview of actual status of accreditation centres can be recognised here:

Deutsche Gesellschaft für Prävention und Anti-Aging Medizin

Deutsche Gesellschaft für Prävention und Anti-Aging Medizin (GSAAM)

Prof. Nixdorff is a member of the board and scientific advisory board. The society addresses prevention and aging medicine. Approximately 1,000 colleagues interested in preventive medicine are members. In addition to evidence, innovation of prevention is also addressed.


Prof. Nixdorff is a member of the Commission on Vascular Function; the corresponding diagnostics are established in the EPC as basic diagnostics (arterial vascular stiffness or elasticity, "man is as old as his vessels")



Prof. Nixdorff works on the Scientific Advisory Board, where he handles the annual theme-heart-weeks and telephone conversations to clarify "heart issues" of the population.

Prevention studies based on the EPC algorithm

Prof. Nixdorff worked as a Research Fellow at Leibniz Institute for Arteriosclerosis Research at the University Hospital Münster under the direction of Prof. Assmann. PROCAM research lives on under the foundation. Here, the PROCAM risk score (the own heart attack risk) underlying the EPC algorithm can be calculated with a calculator.

Prof. Nixdorff is in scientific contact with Dr. Cooper and Dr. Blair since he received the certification "Physical Fitness Specialist" there. The Cooper Institute and Cooper Clinic under the direction of Dr. Cooper is the leading scientific fitness institute from which until now > 700 peer-reviewed articles have resulted and to which the EPC is significantly oriented.

Prof. Nixdorff worked for many years with Prof. Erbel at Johannes Gutenberg University Hospital Mainz, the inaugurator of the Nixdorf Recall Study; a fundamental prevention study. Nomograms of this study are established in the EPC, according to which age and sex referencing of many measurements are made.


In addition to the EPC, Prof. Nixdorff runs a private cardiology practice with a preventive cardiological and non-invasive imaging focus. The use of invasive procedures (cardiac catheterization) can be focused much better.

Professor Nixdorff is medical CEO of the healthcare provider Hanako. Hanako offers health checks to medium-sized and large companies for their employees. Hanako's health checks are based on the EPC's experience, are fully modularised and are carried out by medical teams with mobile devices throughout Germany, without travel or waiting times for participants.


Prof. Nixdorff has collaborated with the radiological and nuclear cardiological colleagues of MVZ radios GmbH ( the "Interdisciplinary Cardiac Imaging Center ((IC) ²)" in the home of the Medical Center Düsseldorf (GrandArc). For cardiac cross sectional diagnostics, an ultra-fast SOMATOM Definition Edge CT (lowest radiation dose, shortest examination duration, highest image quality), a 3T MRI and a D-SPECT gamma camera are available. 


In respect of future development the preventive medical experience of EPC will be complimented by the cooperation with a renowned geneticist, Prof. K. Nayernia. The spatial resolution of modern cross-sectional imaging is about 5 mm in CT and 10 mm in MRI (phenotype). Much earlier detection resp. disposition of (malignant) processes can be achieved by molecular and genetic modalities (genotype). In ECPM for personalised preventive medicine genotype as well as phenotype are assessed in a synthetic information complimentation which professionalises preventive medicine.

Through these networks, the presence on the internet as well as the awareness und knowledge transfer to interested people is enhanced.



To increase Happiness and Longevity


To reduce Morbidity and Mortality


From Prediction to Prevention